Recombinant Human IL-1 Beta Protein
产品特性
| Synonyms: | Interleukin-1 beta; Catabolin; IL1F2; IL1B |
| Product Description: | Recombinant Human Interleukin-1 Beta is produced by our E.coli expression system and the target gene encoding Ala117-Ser269 is expressed. |
| UniProt ID: | P01584 |
| Species: | Human |
| Expression System: | E.coli |
| Tag: | Tag free |
| Predicted MW: | 17.5 KDa |
| SDS-PAGE: | 17 KDa, reducing conditions |
| Formulation: | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5. |
| Endotoxin Level: | Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test. |
| Activity: | Measured by its ability to induce NF-kB signaling in 293-IL1 Res cells. The ED50 for this effect is 20-100 pg/ml. |
| Purity: | >95% |
| Stability and Storage: | Store at ≤-70°C, stable for 6 months after receipt. |
| Store at ≤-70°C, stable for 3 months under sterile conditions after opening. | |
| Please minimize freeze-thaw cycles. |
产品背景
Potent pro-inflammatory cytokine (PubMed:3920526, PubMed:10653850, PubMed:12794819).
Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526).
Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819).
Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744).
产品来源
洱畔科技实验室
