IL-4 Monoclonal antibody
产品特性
| Product Cat#: | 66142-1-Ig |
| Product type: | Primary antibody |
| Antigen: | IL-4 |
| Immunogen: | IL-4 Fusion Protein |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | FC, IF-P, IHC, WB, ELISA |
| Reactivity: | Tested Reactivity: Human, Pig |
| Cited Reactivity: Human, Mouse, Rat, Pig, Bovine | |
| Clonality (clone number): | Monoclonal, 1G2C5 |
| Form: | Liquid |
| Buffer: | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Concentration: | 1264 μg/ml |
| Purity: | Protein A purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | B cell stimulatory factor 1, Binetrakin, BSF 1, BSF1, IL 4, IL4, IL-4, interleukin 4, PS1TP5BP1 |
靶标信息
Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:1993171, PubMed:3016727).
Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:1993171).
Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (PubMed:2521231).
Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity).
Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells (PubMed:10219247, PubMed:11526337, PubMed:18243101).
Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:7721895).
相关文献
1、Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN. Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues. J Immunol. 2022 Nov 1;209(9):1674-1690. doi: 10.4049/jimmunol.2200178. Epub 2022 Sep 23. PMID: 36150727; PMCID: PMC9588758.
2、Hai YP, Saeed MEM, Ponto KA, Elflein HM, Lee ACH, Fang S, Zhou H, Frommer L, Längericht J, Efferth T, Kahaly GJ. A Multicenter, Single-Blind, Case-Control, Immunohistochemical Study of Orbital Tissue in Thyroid Eye Disease. Thyroid. 2022 Dec;32(12):1547-1558. doi: 10.1089/thy.2022.0173. Epub 2022 Oct 31. PMID: 36128805.
3、Zong X, Dong Y, Li Y, Yang L, Li Y, Yang B, Tucker L, Zhao N, Brann DW, Yan X, Hu S, Zhang Q. Beneficial Effects of Theta-Burst Transcranial Magnetic Stimulation on Stroke Injury via Improving Neuronal Microenvironment and Mitochondrial Integrity. Transl Stroke Res. 2020 Jun;11(3):450-467. doi: 10.1007/s12975-019-00731-w. Epub 2019 Sep 12. PMID: 31515743.
