靶标信息
白细胞介素 6(IL-6)是一种由淋巴、非淋巴细胞产生的多功能细胞因子。人 IL-6 的 cDNA 序列有 212 个氨基酸残基,含两个潜在的N-糖基化位点。成熟 IL-6 由疏水 N 末端 28 个氨基酸残基信号肽裂解产生,含184氨基酸残基,其中有四个半胱氨酸残基,分子量为21 kDa。IL-6由多种细胞产生,对免疫应答、急性期反应、造血和神经系统有多方面作用。IL-6的生物学活性主要包括 6 个方面:调节免疫应答、调节造血系统、诱导急性期蛋白、调节肿瘤生长、调节神经内分泌系统和其它。
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