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E-Cadherin (24E10) Rabbit mAb #3195

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
3195
E-Cadherin (24E10) Rabbit mAb #3195
Cell Signaling Technology 有货

产品特性        

产品货号:            3195
规格: 20 μL; 100 μL
物种免疫 :
同种型: IgG
克隆性: 单克隆
免疫原: 使用与人上皮钙粘素蛋白中 Pro780 周围残基相对应的合成肽,对动物进行免疫接种来产生单克隆抗体。
种属反应性: 人, 小鼠
特异性/灵敏度: E-Cadherin (24E10) Rabbit mAb 可检测 E-cadherin 总蛋白的内源水平。该抗体不与相关家族成员发生交叉反应,例如 N-cadherin。
应用: 蛋白质印迹法 1:1000
Simple Western™ 1:10 – 1:50
IHC Leica BOND 1:400 – 1:1600
免疫组织化学(石蜡) 1:400
免疫荧光法(免疫细胞化学) 1:1600
流式细胞术(固定/通透) 1:100 – 1:400
保存: 保存在 10 mM sodium HEPES (pH 7.5)、150 mM NaCl、100 µg/ml BSA、50% 甘油和低于 0.02% 的叠氮化钠中。-20℃ 保存。切勿分装抗体。
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靶标信息

Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333).
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333).
Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
(Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.

产品来源

Cell Signaling Technology