E-cadherin 抗体 (G-10): sc-8426
产品特性
| Product Cat#: | sc-8426 |
| Product type: | Primary antibody |
| Antigen: | E-cadherin |
| Immunogen: | E-cadherin (G-10) is a mouse monoclonal antibody raised against amino acids 600-707 mapping within an extracellular domain of E-cadherin of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | WB, IP, IF, IHC(P) 和 ELISA |
| Reactivity: | Human, Mouse and Rat |
| Clonality (clone number): | Monoclonal, G-10 |
| Form: | Liquid |
| Buffer: | Each vial contains 200 µg IgG1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin. |
| Concentration: | 200 μg/mL |
| Purity: | Protein G purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; cell-CAM 120/80; E-Cadherin; E-cadherin 1; Ecadherin; Epithelial cadherin; Uvomorulin; Arc-1; CD324; CDH1; CDHE; ECAD; LCAM; UVO |
靶标信息
Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333).
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333).
Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
相关文献
1、Hong R, Lim SC, Lee TB, Han SI. Anticancer Effect of Gallic Acid on Acidity-Induced Invasion of MCF7 Breast Cancer Cells. Nutrients. 2023 Aug 16;15(16):3596. doi: 10.3390/nu15163596. PMID: 37630786; PMCID: PMC10458441.
2、Mohamed T, Colciago A, Montagnani Marelli M, Moretti RM, Magnaghi V. Protein kinase C epsilon activation regulates proliferation, migration, and epithelial to mesenchymal-like transition in rat Schwann cells. Front Cell Neurosci. 2023 Aug 14;17:1237479. doi: 10.3389/fncel.2023.1237479. PMID: 37645595; PMCID: PMC10461112.
3、Tang Y, Qian C, Zhou Y, Yu C, Song M, Zhang T, Min X, Wang A, Zhao Y, Lu Y. Activated platelets facilitate hematogenous metastasis of breast cancer by modulating the PDGFR-β/COX-2 axis. iScience. 2023 Aug 23;26(9):107704. doi: 10.1016/j.isci.2023.107704. PMID: 37680480; PMCID: PMC10480622.
4、Ernstsen CV, Riishede A, Iversen AKS, Bay L, Bjarnsholt T, Nejsum LN. E-cadherin and aquaporin-3 are downregulated in wound edges of human chronic wounds. APMIS. 2023 Aug;131(8):403-409. doi: 10.1111/apm.13332. Epub 2023 Jun 2. PMID: 37267058.