靶标信息
Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity).
Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity).
相关文献
1、Viktorsson K, Hååg P, Shah CH, Franzén B, Arapi V, Holmsten K, Sandström P, Lewensohn R, Ullén A. Profiling of extracellular vesicles of metastatic urothelial cancer patients to discover protein signatures related to treatment outcome. Mol Oncol. 2022 Oct;16(20):3620-3641. doi: 10.1002/1878-0261.13288. Epub 2022 Aug 12. PMID: 35838333; PMCID: PMC9580890.
2、Cocola C, Magnaghi V, Abeni E, Pelucchi P, Martino V, Vilardo L, Piscitelli E, Consiglio A, Grillo G, Mosca E, Gualtierotti R, Mazzaccaro D, La Sala G, Di Pietro C, Palizban M, Liuni S, DePedro G, Morara S, Nano G, Kehler J, Greve B, Noghero A, Marazziti D, Bussolino F, Bellipanni G, D’Agnano I, Götte M, Zucchi I, Reinbold R. Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy. Front Cell Neurosci. 2021 Nov 17;15:703431. doi: 10.3389/fncel.2021.703431. PMID: 34867197; PMCID: PMC8636015.
3、van de Vlekkert D, Qiu X, Annunziata I, d’Azzo A. Isolation and Characterization of Exosomes from Skeletal Muscle Fibroblasts. J Vis Exp. 2020 May 16;(159):10.3791/61127. doi: 10.3791/61127. PMID: 32478721; PMCID: PMC8186027.