Anti-ZIC1/2/3 antibody
Specifications
| Product Cat#: | AB-07-2250 |
| Product type: | Primary antibody |
| Antigen: | ZIC1/2/3 |
| Immunogen: | The antiserum was produced against synthesized peptide derived from internal of human ZIC1/2/3. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:750); Immunohistochemistry (1:50-1:100); ELISA (1:15000) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Zinc finger protein ZIC 1, Zinc finger protein of the cerebellum 1, ZIC1 |
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靶标信息
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5′-TGGGTGGTC-3′ (By similarity).
产品来源
洱畔科技实验室
