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Anti-ZFHX3 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-07-2248
Anti-ZFHX3 antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-07-2248
Product type: Primary antibody
Antigen: ZFHX3
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human ZFHX3.
Species immunized: Rabbit
Isotype: IgG
Applications: Immunohistochemistry (1:50-1:100); ELISA (1:7500)
Reactivity: Human, Mouse
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/ml
Purity: Antigen affinity chromatography
Storage: Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Alternative names: Zinc finger homeodomain protein 3; ZFH-3; Alpha-fetoprotein enhancer-binding protein; AT motif-binding factor; AT-binding transcription factor 1
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靶标信息

Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).

产品来源

洱畔科技实验室

文件下载

MSDS-AB-07-2248.pdf (下载257 )