Anti-XRN2 antibody
Specifications
| Product Cat#: | AB-07-2241 |
| Product type: | Primary antibody |
| Antigen: | XRN2 |
| Immunogen: | The antiserum was produced against synthesized peptide derived from internal of human XRN2. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2500); Immunohistochemistry (1:50-1:100); ELISA (1:750) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 5'-3' exoribonuclease 2, EC 3.1.13.-, DHM1-like protein, DHP protein, XRN2 |
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靶标信息
Possesses 5′->3′ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5′ fragment which is subsequently processed to form the mature mRNA and a 3′ fragment which remains attached to the elongating polymerase. The processive degradation of this 3′ fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
产品来源
洱畔科技实验室
