Anti-ULK1 antibody
产品特性
| Product Cat#: | AB-06-4539 |
| Product type: | Primary antibody |
| Antigen: | ULK1 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:40-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal (JA58-36) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH 7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ATG 1 antibody |
| ATG1 antibody | |
| ATG1 autophagy related 1 homolog antibody | |
| ATG1A antibody | |
| Autophagy related protein 1 homolog antibody | |
| Autophagy-related protein 1 homolog antibody | |
| FLJ38455 antibody | |
| FLJ46475 antibody | |
| HATG1 antibody | |
| KIAA0722 antibody | |
| Serine/threonine protein kinase ULK1 antibody | |
| Serine/threonine protein kinase Unc51.1 antibody | |
| Serine/threonine-protein kinase ULK1 antibody | |
| ULK 1 antibody | |
| ULK1 antibody | |
| ULK1_HUMAN antibody | |
| Unc 51 (C. elegans) like kinase 1 antibody | |
| UNC 51 antibody | |
| Unc 51 like kinase 1 antibody | |
| Unc-51 like kinase 1 (C. elegans) antibody | |
| Unc-51-like kinase 1 antibody | |
| UNC51 antibody | |
| UNC51, C. elegans, homolog of antibody | |
| Unc51.1 antibody |
靶标信息
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy.
产品来源
洱畔科技实验室