Anti-TRIM23 antibody
产品特性
| Product Cat#: | AB-06-4448 |
| Product type: | Primary antibody |
| Antigen: | TRIM23 |
| Immunogen: | KLH conjugated synthetic peptide derived from human TRIM23 201-300/574 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-1:800) |
| Reactivity: | Human, Mouse, Rat, Dog, Pig, Horse, Sheep |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 10 mM PBS buffer (pH 7.4), 1% BSA, 15 mM NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | ADP ribosylation factor domain protein 1 |
| ARF domain protein 1 | |
| ARFD1 | |
| GTP binding protein ARD 1 | |
| TRI23_HUMAN | |
| N-acetyltransferase ARD1 human homolog of | |
| N-acetyltransferase homolog of S. cerevisiae ARD1 | |
| TRIM23 |
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靶标信息
Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates ‘Lys-27’-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.
产品来源
洱畔科技实验室