Anti-TCF4 antibody
产品特性
| Product Cat#: | AB-06-4290 |
| Product type: | Primary antibody |
| Antigen: | TCF4 |
| Immunogen: | Synthetic peptide (KLH-coupled) within human TCF4 N-terminal. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunohistochemistry (1:50-1:200); Flow Cytometry (1:50-1:200); Immunocytochemistry (1:400-1:2000) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Peptide affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | BHLHb19 antibody |
| Class B basic helix-loop-helix protein 19 antibody | |
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| ITF 2 antibody | |
| ITF-2 antibody | |
| ITF2 antibody | |
| ITF2_HUMAN antibody | |
| MGC149723 antibody | |
| MGC149724 antibody | |
| PTHS antibody | |
| SEF 2 antibody | |
| SEF-2 antibody | |
| SEF2 1 antibody | |
| SEF2 1A antibody | |
| SEF2 1B antibody | |
| SEF2 1D antibody | |
| SEF2 antibody | |
| SL3 3 enhancer factor 2 antibody | |
| SL3-3 enhancer factor 2 antibody | |
| TCF 4 antibody | |
| TCF-4 antibody | |
| TCF4 antibody | |
| Transcription factor 4 antibody | |
| Transcription factor 4, isoform C antibody | |
| Transcription factor 4, isoform D antibody | |
| Transcription factor 4, isoform E antibody | |
| Transcription factor 4, isoform L antibody | |
| Transcription factor 4, isoform M antibody | |
| Transcription factor 4, isoform R antibody |
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靶标信息
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5′-CCTTTGATC-3′ in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
产品来源
洱畔科技实验室
