Anti-Survivin antibody
产品特性
| Product Cat#: | AB-06-4240 |
| Product type: | Primary antibody |
| Antigen: | Survivin |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:2000); Immunoprecipitation; Immunohistochemistry (1:60-1:200) |
| Reactivity: | Mouse, Rat |
| Clonality (clone number): | Monoclonal (SR44-02) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4),1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | API4 antibody |
| Apoptosis inhibitor 4 antibody | |
| Apoptosis inhibitor survivin antibody | |
| Apoptosis inhibitor4 antibody | |
| Baculoviral IAP repeat containing 5 antibody | |
| Baculoviral IAP repeat containing protein 5 antibody | |
| Baculoviral IAP repeat-containing protein 5 antibody | |
| BIRC 5 antibody | |
| BIRC5 antibody | |
| BIRC5_HUMAN antibody | |
| EPR 1 antibody | |
| IAP4 antibody | |
| Survivin variant 3 alpha antibody | |
| SVV antibody | |
| TIAP antibody |
靶标信息
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at ‘Thr-3’ (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7.
产品来源
洱畔科技实验室
