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Anti-SUN2 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-4235
Anti-SUN2 antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-4235
Product type: Primary antibody
Antigen: SUN2
Immunogen: Recombinant protein within human SUN2 aa 500-700.
Species immunized: Rabbit
Isotype: IgG
Applications: Immunofluorescence(1:60-1:100); Western Blot (1:600-1:2000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:60-1:100); Flow Cytometry (1:60-1:100)
Reactivity: Mouse, Rat and Human
Clonality (clone number): Monoclonal (JG39-52)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: FRIGG antibody
KIAA0668 antibody
Nuclear envelope protein antibody
Protein unc-84 homolog B antibody
Rab5 interacting protein antibody
Sad1 and UNC84 domain containing 2 antibody
Sad1 unc-84 domain protein 2 antibody
Sad1 unc84 domain protein antibody
Sad1/unc-84 protein-like 2 antibody
Sad1/unc84 protein-like antibody
SUN domain-containing protein 2 antibody
UNC 84B antibody
Unc84 homolog B (C. elegans) antibody
Unc84 homolog B antibody
Unc84, C. elegans, homolog of, B antibody
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靶标信息

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-4235.pdf (下载158 )