购物车里没有产品

Anti-STAT1 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-4199
Anti-STAT1 antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-4199
Product type: Primary antibody
Antigen: STAT1
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:1000); Immunocytochemistry (1:200)
Reactivity: Mouse, Rat and Human
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Concentration: 1 mg/ml
Purity: Peptide affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Signal transducer and activator of transcription 1 91kD antibody
CANDF7 antibody
DKFZp686B04100 antibody
IMD31A antibody
IMD31B antibody
IMD31C antibody
ISGF 3 antibody
ISGF-3 antibody
OTTHUMP00000163552 antibody
OTTHUMP00000165046 antibody
OTTHUMP00000165047 antibody
OTTHUMP00000205845 antibody
Signal transducer and activator of transcription 1 91kDa antibody
Signal transducer and activator of transcription 1 antibody
Signal transducer and activator of transcription 1, 91kD antibody
Signal transducer and activator of transcription 1-alpha/beta antibody
STAT 1 antibody
Stat1 antibody
STAT1_HUMAN antibody
STAT91 antibody
Transcription factor ISGF 3 components p91 p84 antibody
Transcription factor ISGF-3 components p91/p84 antibody
展开

靶标信息

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus . ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-4199.pdf (下载202 )