Anti-Smad2 antibody
产品特性
| Product type: | Primary antibody |
| Antigen: | Smad2 |
| Immunogen: | Peptide |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Western Blot (1:800-1:1000); Immunoprecipitation (1-3 μg per 100-500 μg of total protein(1 ml of cell lysate));Immunofluorescence ((1:40-1:500)); Flow Cytometry (1:40-1:500) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (4D3) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | hMAD 2 antibody |
| hMAD 3 antibody | |
| hSMAD2 antibody | |
| hSMAD3 antibody | |
| Mad related protein 2 antibody | |
| MADH2 antibody | |
| MADH3 antibody | |
| MADR2 antibody | |
| Mothers against DPP homolog 2 antibody | |
| Mothers against DPP homolog 3 antibody | |
| Sma and Mad related protein 2 antibody | |
| SMA and MAD related protein 3 antibody | |
| SMAD 2 antibody | |
| SMAD 3 antibody | |
| SMAD family member 2 antibody | |
| SMAD family member 3 antibody | |
| smad2+3 antibody | |
| smad2/3 antibody |
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靶标信息
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
产品来源
洱畔科技实验室
