Anti-SKP2 antibody
产品特性
| Product Cat#: | AB-06-4077 |
| Product type: | Primary antibody |
| Antigen: | SKP2 |
| Immunogen: | KLH conjugated synthetic peptide derived from human Skp2 351-424/424 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:300-1:2000 ); Immunohistochemistry-Paraffin ( 1:500-800 ); Flow Cytometry ( 1-2μg/Test ) |
| Reactivity: | Mouse, Rat, Cow, Rabbit and Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 50 % glycerol, 0.05 % NaN3, 0.03 % Proclin300. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | p45skp2 |
| skp2p45 | |
| p45 | |
| skp2 p45 | |
| S-phase Kinase-associated Protein 2 | |
| SKP2 |
靶标信息
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.
产品来源
洱畔科技实验室
