Anti-SIRT3 antibody
产品特性
| Product Cat#: | AB-06-4067 |
| Product type: | Primary antibody |
| Antigen: | SIRT3 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:400-1:1000 ): Flow Cytometry ( 1:80-1:200 ) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal ( 2A-1B ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | hSIRT 3 Antibody |
| hSIRT3 Antibody | |
| Mitochondrial Nicotinamide Adenine Dinucleotide Dependent Deacetylase Antibody | |
| NAD Dependent Deacetylase Sirtuin 3 Mitochondrial Antibody | |
| NAD-dependent Protein Deacetylase Sirtuin-3, Mitochondrial Antibody | |
| Regulatory Protein SIR2 Homolog 3 Antibody | |
| Silent Mating Type Information Regulation 2 S.cerevisiae Homolog 3 Antibody | |
| Sir 2 Like 3 Antibody | |
| SIR 2 Like protein 3Antibody | |
| SIR 3 Antibody | |
| SIR2 L3 Antibody | |
| Sir2 Like 3 Antibody | |
| SIR2 Like Protein 3 Antibody | |
| SIR2-like Protein 3 Antibody | |
| SIR2L3 Antibody | |
| SIR3_HUMAN Antibody | |
| SIRT 3 Antibody | |
| SIRT3 Antibody | |
| Sirtuin 3 Antibody | |
| Sirtuin Silent Mating Type Information Regulation 2 Homolog 3 (S. cerevisiae) Antibody |
靶标信息
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).
产品来源
洱畔科技实验室