Anti-SHP-2 (Ab-580) antibody
产品特性
| Product Cat#: | AB-07-3724 |
| Product type: | Primary antibody |
| Antigen: | SHP-2 (Ab-580) |
| Immunogen: | A synthetic peptide derived from human SHP-2 (Ab-580). The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500~1:3000); ELISA (1:20000); Immunohistochemistry (1:50~1:100) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | EC 3.1.3.48, PTN11, PTP-1D, PTP-2C, PTP2C, PTPN11, Protein-tyrosine phosphatase 2C, Protein-tyrosine phosphatase, non-receptor type 11, SH-PTP2, SH-PTP3, SHPTP2 |
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靶标信息
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at ‘Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
产品来源
洱畔科技实验室
