Anti-SF3B3 antibody
产品特性
| Product Cat#: | AB-06-4030 |
| Product type: | Primary antibody |
| Antigen: | SF3B3 |
| Immunogen: | Recombinant protein within the C-terminus of human SF3B3. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:600-1:1000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:60-1:100); Flow Cytometry (1:60-1:100) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (JG63-53) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | KIAA0017 antibody |
| Pre mRNA splicing factor SF3b 130 kDa subunit antibody | |
| Pre-mRNA-splicing factor SF3b 130 kDa subunit antibody | |
| RSE1 antibody | |
| SAP 130 antibody | |
| SAP130 antibody | |
| SF3b130 antibody | |
| SF3B3 antibody | |
| SF3B3_HUMAN antibody | |
| Spliceosome associated protein 130 antibody | |
| Spliceosome-associated protein 130 antibody | |
| Splicing factor 3b subunit 3 130kD antibody | |
| Splicing factor 3B subunit 3 antibody | |
| STAF130 antibody |
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靶标信息
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:10490618, PubMed:10882114, PubMed:27720643, PubMed:28781166). SF3B complex is required for ‘A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the ‘E’ complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).
产品来源
洱畔科技实验室
