Anti-SERCA2 antibody
产品特性
| Product Cat#: | AB-06-4010 |
| Product type: | Primary antibody |
| Antigen: | SERCA2 |
| Immunogen: | Recombinant protein. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunofluorescence; Western Blot (1:1000); Immunohistochemistry (1:60-1:200); Immunocytochemistry (1:60-1:200); Flow Cytometry (1:40-1:100) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (JM10-20) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | AT2A2_HUMAN antibody |
| Atp2a2 antibody | |
| ATP2B antibody | |
| ATPase Ca++ transporting cardiac muscle slow twitch 2 antibody | |
| Calcium pump 2 antibody | |
| Calcium-transporting ATPase sarcoplasmic reticulum type antibody | |
| Calcium-transporting ATPase sarcoplasmic reticulum type slow twitch skeletal muscle isoform antibody | |
| Cardiac Ca2+ ATPase antibody | |
| DAR antibody | |
| DD antibody | |
| Endoplasmic reticulum class 1/2 Ca(2+) ATPase antibody | |
| MGC45367 antibody | |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 antibody | |
| SERCA 2 antibody | |
| SERCA2 antibody | |
| serca2a antibody | |
| slow twitch skeletal muscle isoform antibody |
靶标信息
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca2+ signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).
产品来源
洱畔科技实验室
