Anti-SCF antibody
产品特性
| Product Cat#: | AB-06-3976 |
| Product type: | Primary antibody |
| Antigen: | SCF |
| Immunogen: | Amino acids 26-214 of SCF of human origin. |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:300-1:2000); Immunoprecipitation:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate); Immunohistochemistry (1:60-1:500); Immunofluorescence(1:60-1:500 ) |
| Reactivity: | Mouse, Rat and Human |
| Clonality (clone number): | Monoclonal (4G5) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | C kit ligand antibody |
| C-kit ligand antibody | |
| Ckit ligand antibody | |
| DCUA antibody | |
| DFNA69 antibody | |
| DKFZp686F2250 antibody | |
| Familial progressive hyperpigmentation 2 antibody | |
| FPH2 antibody | |
| FPHH antibody | |
| KIT ligand antibody | |
| Kitl antibody | |
| KITLG antibody | |
| KL 1 antibody | |
| KL1 antibody | |
| Mast cell growth factor antibody | |
| MGF antibody | |
| MGF stem cell factor antibody | |
| SCF antibody | |
| SCF_HUMAN antibody | |
| SF antibody | |
| SHEP7 antibody | |
| sKITLG antibody | |
| Soluble KIT ligand antibody | |
| Steel factor antibody | |
| steel, mouse, homolog of antibody | |
| Stem cell factor antibody | |
| Stem cell factor precursor antibody |
靶标信息
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
产品来源
洱畔科技实验室