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Anti-PI 3 Kinase Catalytic Subunit Alpha antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-3570
Anti-PI 3 Kinase Catalytic Subunit Alpha antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-357
Product type: Primary antibody
Antigen: PI 3 Kinase Catalytic Subunit Alpha
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:500-1:1000); Immunoprecipitation; Immunofluorescence; Immunocytochemistry (1:50-1:200)
Reactivity: Human, Mouse
Clonality (clone number): Monoclonal (SJ0186)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: 5-bisphosphate 3-kinase 110 kDa Catalytic Subunit Alpha antibody
5-bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform antibody
caPI3K antibody
CLOVE antibody
CWS5 antibody
MCAP antibody
MCM antibody
MCMTC antibody
MGC142161 antibody
MGC142163 antibody
p110 alpha antibody
p110alpha antibody
Phosphatidylinositol 3 Kinase Catalytic Alpha Polypeptide antibody
Phosphatidylinositol 3 Kinase Catalytic 110 KD Alpha antibody
Phosphatidylinositol 4 5 Bisphosphate 3 Kinase Catalytic Subunit Alpha antibody
Phosphatidylinositol 4 5 Bisphosphate 3 Kinase Catalytic Subunit Alpha Isoform antibody
Phosphatidylinositol 4,5 Bisphosphate 3 Kinase 110 kDa Catalytic Subunit Alpha antibody
Phosphatidylinositol-4 antibody
Phosphoinositide 3 Kinase Catalytic Alpha Polypeptide antibody
PI3 Kinase p110 Subunit Alpha antibody
PI3-Kinase Subunit Alpha antibody
PI3K antibody
PI3K-Alpha antibody
PI3KC A antibody
PIK3C A antibody
Pik3ca antibody
PK3CA antibody
PK3CA_HUMAN antibody
PtdIns 3 Kinase p110 antibody
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靶标信息

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-3570.pdf (下载132 )