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Anti-Phospho-Raf1 (S259) antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-3541
Anti-Phospho-Raf1 (S259) antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-3541
Product type: Primary antibody
Antigen: Phospho-Raf1 (S259)
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser259 of human Raf1
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:900-1:2000); Immunohistochemistry (1:40-1:200)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Monoclonal (SD85-07)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA; 40% glycerol, 0.05% NaN3.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: C Raf antibody
C-raf antibody
C-Raf proto-oncogene, serine/threonine kinase antibody
CMD1NN antibody
Craf 1 transforming gene antibody
CRaf antibody
Craf1 transforming gene antibody
EC 2.7.11.1 antibody
kinase Raf1 antibody
Murine sarcoma 3611 oncogene 1 antibody
NS5 antibody
Oncogene MIL antibody
Oncogene RAF1 antibody
OTTHUMP00000160218 antibody
OTTHUMP00000207813 antibody
OTTHUMP00000209389 antibody
Protein kinase raf 1 antibody
Proto-oncogene c-RAF antibody
Raf 1 antibody
Raf 1 proto oncogene serine/threonine kinase antibody
RAF antibody
Raf proto oncogene serine/threonine protein kinase antibody
RAF proto-oncogene serine/threonine-protein kinase antibody
RAF-1 antibody
RAF1 antibody
RAF1_HUMAN antibody
Similar to murine leukemia viral (V-raf-1) oncogene homolog 1 antibody
TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV antibody
V raf 1 murine leukemia viral oncogene homolog 1 antibody
V-raf murine sarcoma viral oncogene homolog 1 antibody
V-raf-1 murine leukemia viral oncogene-like protein 1 antibody
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靶标信息

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at ‘Ser-75’. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-3541.pdf (下载71 )