Anti-p21 Antibody
产品特性
| Product Cat#: | AB-06-4976 |
| Product type: | Primary antibody |
| Antigen: | p21 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Immunohistochemistry-Paraffin (1:200-1:400) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal, A8C12 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 40% glycerol, 0.1% BSA, 0.05% NaN3. |
| Concentration: | 1 mg/mL |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | CAP20 antibody |
| CDK-interacting protein 1 antibody | |
| CDKI antibody | |
| CDKN1 antibody | |
| Cdkn1a antibody | |
| CDN1A_HUMAN antibody | |
| CIP1 antibody | |
| Cyclin Dependent Kinase Inhibitor 1A antibody | |
| Cyclin-dependent kinase inhibitor 1 antibody | |
| Cyclin-dependent kinase inhibitor 1A (P21) antibody | |
| Cyclin-dependent kinase inhibitor 1A (p21, Cip1) antibody | |
| DNA Synthesis Inhibitor antibody | |
| MDA-6 antibody | |
| MDA6 antibody | |
| Melanoma differentiation-associated protein 6 antibody | |
| Melanoma differentiation-associated protein antibody | |
| p21 antibody | |
| P21 protein antibody | |
| p21CIP1 antibody | |
| p21Cip1/Waf1 antibody | |
| p21WAF antibody | |
| PIC1 antibody | |
| SDI1 antibody | |
| SLC12A9 antibody | |
| WAF1 antibody | |
| Wild type p53 activated fragment 1 (WAF1) antibody | |
| Wild type p53 activated fragment 1 antibody | |
| Wildtype p53-activated fragment 1 antibody |
靶标信息
Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657).
Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity).
Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
产品来源
洱畔科技实验室
