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Anti-OTUB1 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 Quantity  
AB-07-3395
Anti-OTUB1 antibody
洱畔/Erpan Tech In stock

产品特性        

Product Cat#: AB-07-3395
Product type: Primary antibody
Antigen: OTUB1
Immunogen: A synthetic peptide derived from human OTUB1. The exact amino-acid sequence is proprietary.
Species immunized: Rabbit
Isotype: IgG
Applications: ELISA (1:10000); Western Blot (1:500-1:2500)
Reactivity: Human, Mouse, Rat
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: PBS (without Mg2+ and Ca2+ ), pH 7.4, 0.02% sodium azide and 50% glycerol
Concentration: 1 mg/ml
Purity: Antigen affinity chromatography
Storage: Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles.
Alternative names: Deubiquitinating enzyme OTUB1; FLJ20113; FLJ40710; hOTU1; HSPC263; MGC111158; MGC4584; OTB1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding
protein 1; OTU-domain Ubal-binding 1; OTU1; OTUB1; Otubain-1; Ubiquitin thioesterase OTUB1; Ubiquitin-specific protease otubain 1; Ubiquitin-specific-processing protease OTUB1
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靶标信息

Hydrolase that can specifically remove ‘Lys-48’-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of ‘Lys-48’-linked polyubiquitin chains, but not ‘Lys-63’-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to ‘Lys-48’-linked ubiquitin.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-07-3395.pdf (下载75 )