Anti-OR2AT4 antibody
产品特性
| Product Cat#: | AB-07-0962 |
| Product type: | Primary antibody |
| Antigen: | OR2AT4 |
| Immunogen: | A synthetic peptide derived from human OR2AT4. The exact amino-acid sequence is proprietary. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunofluorescence (1:100-1:500); ELISA (1:15000) |
| Reactivity: | Human |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | PBS (without Mg2+ and Ca2+ ), pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol |
| Concentration: | 1 mg/ml |
| Purity: | Antigen affinity chromatography |
| Storage: | Aliquot and freeze at -20°C. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Olfactory receptor 2AT4; Olfactory receptor OR11-265 |
靶标信息
Olfactory receptor (PubMed:24999593, PubMed:30228264). Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264). Endogenous ligand is unknown (Probable). The activity of this receptor is propably mediated by G proteins which induce elevation of intracellular Ca2+, a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593). Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264).Molecular function:G protein-coupled receptor activity ;olfactory receptor activity.Biological process:G protein-coupled receptor signaling pathway;positive regulation of ERK1 and ERK2 cascade.
产品来源
洱畔科技实验室
