产品特性

Product Cat#:	AB-06-3112
Product type:	Primary antibody/Secondary antibody
Antigen:	NF2
Immunogen:	KLH conjugated synthetic peptide derived from human NF2 401-550/590
Species immunized:	Rabbit
Isotype:	IgG
Applications:	Western Blot (1:200-1:2000)
Reactivity:	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
Clonality (clone number):	Polyclonal
Form:	Liquid
Buffer:	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration:	1 mg/ml
Purity:	Protein A affinity purified
Storage:	Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names:	neurofibromatosis type 2
	CAN
	BANF
	Bilateral acoustic neuroma
	Moesin ezrin radixin like protein
	Moesin ezrin radizin like protein
	Merlin
	Neurofibromatosis 2
	ACN
	Bilateral acoustic neuroma
	MERL_HUMAN
	Merlin
	Moesin ezrin radizin like
	Moesin-ezrin-radixin-like protein
	Neurofibromatosis type 2
	Neurofibromin-2
	NF 2
	Nf2
	Neurofibromatosis2
	Neurofibromin 2
	Neurofibromin2
	Schwannomerlin
	NF-2
	SCH

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靶标信息

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-3112.pdf (下载101 )