Anti-NF-kB p65 antibody (KO Validated)
产品特性
| Product Cat#: | AB-06-3128 |
| Product type: | Primary antibody |
| Antigen: | NF-kB p65 |
| Immunogen: | Synthetic peptide within human NF-kB p65 aa 490-540. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Immunocytochemistry/Immunofluorescence (1:100-1:200); Immunohistochemistry-Paraffin (1:100-1:200); Immunoprecipitation; Flow Cytometry (1:40-1:100) |
| Reactivity: | Mouse and Human |
| Clonality (clone number): | Monoclonal (SZ10-04) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Avian reticuloendotheliosis viral (v rel) oncogene homolog A antibody |
| MGC131774 antibody | |
| NF kappa B p65delta3 antibody | |
| NFKB3 antibody | |
| Nuclear Factor NF Kappa B p65 Subunit antibody | |
| Nuclear factor NF-kappa-B p65 subunit antibody | |
| Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 antibody | |
| Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 antibody | |
| OTTHUMP00000233473 antibody | |
| OTTHUMP00000233474 antibody | |
| OTTHUMP00000233475 antibody | |
| OTTHUMP00000233476 antibody | |
| OTTHUMP00000233900 antibody | |
| p65 antibody |
靶标信息
Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF kB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp kB sequence in the immunoglobulin k light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFkB is activated and NFkB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.
产品来源
洱畔科技实验室
