产品特性

Product Cat#:	AB-06-3089
Product type:	Primary antibody
Antigen:	Netrin 1
Immunogen:	KLH conjugated synthetic peptide derived from human NtN1 501-604/604
Species immunized:	Rabbit
Isotype:	IgG
Applications:	Western Blot (1:200-1:2000); Immunohistochemistry-Paraffin (1:500-800)
Reactivity:	Human, Mouse, Rat, Chicken, Dog, Pig, Cow
Clonality (clone number):	Polyclonal
Form:	Liquid
Buffer:	0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration:	1 mg/ml
Purity:	Protein A affinity purified
Storage:	Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names:	Netrin-1	Netrin1	Netrin 1	Ntn 1	NTN 1L	Ntn1	Ntn-1	NTN1L

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靶标信息

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-3089.pdf (下载131 )