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Anti-Myosin Light Chain Kinase antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-3033
Anti-Myosin Light Chain Kinase antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-3033
Product type: Primary antibody
Antigen: Myosin Light Chain Kinase
Immunogen: Recombinant protein
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:2000-1:10000); Immunohistochemistry (1:100-1:500); Flow Cytometry (1:50-1:100); Immunocytochemistry (1:100-1:500); Immunofluorescence
Clonality (clone number): Monoclonal (SU40-06)
Form: Liquid
Buffer: Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles
Alternative names: Deglutamylated form antibody
DKFZp686I10125 antibody
EC 2.7.11.18 antibody
FLJ12216 antibody
Kinase related protein antibody
Kinase-related protein antibody
KRP antibody
MLCK antibody
MLCK1 antibody
MLCK108 antibody
MLCK210 antibody
MSTP083 antibody
MYLK antibody
MYLK_HUMAN antibody
MYLK1 antibody
Myosin light chain kinase antibody
Myosin light polypeptide kinase antibody
OTTHUMP00000180642 antibody
OTTHUMP00000180643 antibody
SmMLCK antibody
Smooth muscle antibody
Smooth muscle myosin light chain kinase antibody
Telokin antibody
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靶标信息

Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca2+ entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis.

产品来源

洱畔科技实验室

文件下载

MSDS-AB-06-3033.pdf (下载91 )