Anti-MIB1 antibody
产品特性
| Product Cat#: | AB-06-2883 |
| Product type: | Primary antibody |
| Antigen: | MIB1 |
| Immunogen: | Recombinant protein within N-terminal human Mib1 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500); Immunohistochemistry (1:50-1:200); Immunocytochemistry (1:50-1:200) |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (JG69-34) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% Glycerol, 0.05% NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles |
| Alternative names: | DAPK-interacting protein 1 antibody |
| Dip 1 antibody | |
| DIP-1 antibody | |
| Dip1 antibody | |
| E3 ubiquitin protein ligase MIB 1 antibody | |
| E3 ubiquitin protein ligase MIB1 antibody | |
| E3 ubiquitin-protein ligase mib1 antibody | |
| KIAA1323 antibody | |
| LVNC7 antibody | |
| MIB antibody | |
| Mib1 antibody | |
| MIB1_HUMAN antibody | |
| Mind bomb homolog 1 antibody | |
| Mindbomb E3 ubiquitin protein ligase 1 antibody | |
| Ubiquitin ligase mind bomb antibody | |
| Zinc finger ZZ type with ankyrin repeat domain protein 2 antibody | |
| ZZANK2 antibody | |
| ZZZ6 antibody |
展开
靶标信息
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates ‘Lys-63’-linked polyubiquitination of TBK1, which probably participates in kinase activation.
产品来源
洱畔科技实验室
