Anti-LRP6 antibody
产品特性
| Product Cat#: | AB-06-2739 |
| Product type: | Primary antibody |
| Antigen: | LRP6 |
| Immunogen: | Amino acids 1314-1613 of LRP6 of human origin |
| Species immunized: | Mouse |
| Isotype: | IgG1 |
| Applications: | Western Blot (1:100-1:1000); Immunoprecipitation (1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) ); Immunohistochemistry (1:50-1:500); Immunofluorescence (1:50-1:500);Immunohistochemistry-Paraffin |
| Reactivity: | Human, Mouse |
| Clonality (clone number): | Monoclonal (1G8) |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | ADCAD2 antibody |
| C030016K15Rik antibody | |
| Cd antibody | |
| FLJ90062 antibody | |
| FLJ90421 antibody | |
| Low density lipoprotein receptor related protein 6 antibody | |
| Low-density lipoprotein receptor-related protein 6 antibody | |
| LRP-6 antibody | |
| LRP6 antibody | |
| LRP6_HUMAN antibody | |
| OTTHUMP00000238979 antibody | |
| OTTHUMP00000238980 antibody | |
| OTTHUMP00000238982 antibody |
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靶标信息
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
产品来源
洱畔科技实验室
