Anti-KMT5A/SETD8/Pr-SET7 antibody
产品特性
| Product Cat#: | AB-06-2636 | |||||||||||||||||||||||||||
| Product type: | Primary antibody | |||||||||||||||||||||||||||
| Antigen: | KMT5A/SETD8/Pr-SET7 | |||||||||||||||||||||||||||
| Immunogen: | Recombinant protein | |||||||||||||||||||||||||||
| Species immunized: | Rabbit | |||||||||||||||||||||||||||
| Isotype: | IgG | |||||||||||||||||||||||||||
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (1:50-1:100) | |||||||||||||||||||||||||||
| Reactivity: | Human, Mouse | |||||||||||||||||||||||||||
| Clonality (clone number): | Monoclonal | |||||||||||||||||||||||||||
| Form: | Liquid | |||||||||||||||||||||||||||
| Buffer: | TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. | |||||||||||||||||||||||||||
| Concentration: | 1 mg/ml | |||||||||||||||||||||||||||
| Purity: | Protein A affinity purified | |||||||||||||||||||||||||||
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. | |||||||||||||||||||||||||||
| Alternative names: | H4 K20 HMTase antibody | H4 K20 Specific Histone Methyltransferase antibody | H4-K20-HMTase SETD8 antibody | Histone H4 K20 Methyltransferase antibody | Histone lysine N Methyltransferase H4 lysine 20 specific antibody | Histone-lysine N-Methyltransferase SETD8 antibody | Lysine N-Methyltransferase 5A antibody | N-Lysine Methyltransferase SETD8 antibody | Pr SET 7 antibody | Pr SET7 antibody | PR-Set7 antibody | PR/SET Domain Containing Protein 07 antibody | PR/SET Domain Containing Protein 8 antibody | PR/SET Domain-Containing Protein 07 antibody | PR/SET07 antibody | PrSET7 antibody | SET 07 antibody | SET 8 antibody | SET Domain Containing (Lysine Methyltransferase) 8 antibody | SET Domain Containing 8 antibody | SET Domain Containing Lysine Methyltransferase 8 antibody | SET Domain Containing Protein 8 antibody | SET Domain-Containing Protein 8 antibody | SET07 antibody | SET8 antibody | SETD 8 antibody | setd8 antibody | SETD8_HUMAN antibody |
靶标信息
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates ‘Lys-20’ of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at ‘Lys-382’, leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
产品来源
洱畔科技实验室
