Anti-Ki67 Recombinant Rabbit Monoclonal antibody
产品特性
| Product Cat#: | AB-06-5013 |
| Product type: | Primary antibody |
| Antigen: | Ki67 |
| Immunogen: | Synthetic peptide within human Ki67. |
| Molecular weight: | Predicted band size: 345-395 kDa; |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Immunohistochemistry-Paraffin (1:5000-1:10000); Immunocytochemistry (1:100-1:200); Immunofluorescence (1:250-1:500); Flow Cytometry (1:500-1:1000) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, SR00-02 |
| Form: | Liquid |
| Buffer: | 1*PBS buffer (pH7.4), 40% glycerol, 0.1% BSA, 0.05% NaN3. |
| Concentration: | 1 mg/mL |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Antigen identified by monoclonal antibody Ki 67 antibody |
| Antigen identified by monoclonal antibody Ki-67 antibody | |
| Antigen KI-67 antibody | |
| Antigen KI67 antibody | |
| Antigen Ki67 antibody | |
| KI67_HUMAN antibody | |
| KIA antibody | |
| Marker of proliferation Ki-67 antibody | |
| MIB 1 antibody | |
| MIB antibody | |
| MKI67 antibody | |
| PPP1R105 antibody | |
| Proliferation marker protein Ki-67 antibody | |
| Proliferation related Ki 67 antigen antibody | |
| Protein phosphatase 1 regulatory subunit 105 antibody | |
| RP11-380J17.2 antibody |
靶标信息
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226).
Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226).
Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226).
Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551).
Does not contribute to the internal structure of mitotic chromosomes (By similarity).
May play a role in chromatin organization (PubMed:24867636).
It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable)
产品来源
洱畔科技实验室
