Anti-KBTBD8 antibody
产品特性
| Product Cat#: | AB-06-2553 | ||||||||||||||||||
| Product type: | Primary antibody | ||||||||||||||||||
| Antigen: | KBTBD8 | ||||||||||||||||||
| Immunogen: | Recombinant protein | ||||||||||||||||||
| Species immunized: | Mouse | ||||||||||||||||||
| Isotype: | IgG1 | ||||||||||||||||||
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (1:50-1:100) | ||||||||||||||||||
| Reactivity: | Human | ||||||||||||||||||
| Clonality (clone number): | Monoclonal (6G-8A) | ||||||||||||||||||
| Form: | Liquid | ||||||||||||||||||
| Buffer: | 10 mM Tris-HCl buffer (pH7.4), 1% BSA, 50% Glycerol, 0.03% Proclin300. | ||||||||||||||||||
| Concentration: | 1 mg/ml | ||||||||||||||||||
| Purity: | Protein A affinity purified | ||||||||||||||||||
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. | ||||||||||||||||||
| Alternative names: | AU040152 antibody | FLJ57592 antibody | KBTB8_HUMAN antibody | Kbtbd8 antibody | Kelch Repeat and BTB (POZ) Domain Containing 8 antibody | Kelch Repeat and BTB Domain Containing Protein 8 antibody | Kelch Repeat and BTB Domain-Containing Protein 8 antibody | KIAA1842 antibody | MGC91215 antibody | mKIAA1842 antibody | OTTHUMP00000213470 antibody | RGD1563166 antibody | SSEC 51 antibody | SSEC51 antibody | T cell Activation Kelch Repeat Protein antibody | T-cell Activation Kelch Repeat Protein antibody | TA KRP antibody | TA-KRP antibody | Takrp antibody |
展开
靶标信息
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
产品来源
洱畔科技实验室
