Anti-JARID2 antibody
产品特性
| Product Cat#: | AB-06-2531 |
| Product type: | Primary antibody |
| Antigen: | JARID2 |
| Immunogen: | Recombinant protein |
| Species immunized: | Mouse |
| Isotype: | IgG2a |
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (1:100-1:200); Immunocytochemistry (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified. |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | JARD2 antibody |
| JARD2_HUMAN antibody | |
| JARID2 antibody | |
| JMJ antibody | |
| Jumonji AT rich interactive domain 2 antibody | |
| Jumonji homolog antibody | |
| Jumonji like protein antibody | |
| Jumonji protein antibody | |
| Jumonji/ARID domain containing protein 2 antibody | |
| Jumonji/ARID domain-containing protein 2 antibody | |
| Protein Jumonji antibody |
靶标信息
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of ‘Lys-27’ of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of ‘Lys-9’ of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
产品来源
洱畔科技实验室
