Anti-HIF1AN antibody
产品特性
| Product Cat#: | AB-06-2160 |
| Product type: | Primary antibody |
| Antigen: | HIF1AN |
| Immunogen: | Recombinant protein within human HIF1AN aa 1-200. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:40-1:00); Immunocytochemistry (1:100-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JG37-66) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DKFZp762F1811 antibody |
| Factor inhibiting HIF-1 antibody | |
| Factor inhibiting HIF1 antibody | |
| FIH 1 antibody | |
| FIH-1 antibody | |
| FIH1 antibody | |
| FLJ20615 antibody | |
| FLJ22027 antibody | |
| HIF1AN antibody | |
| HIF1N_HUMAN antibody | |
| Hypoxia inducible factor 1 alpha inhibitor antibody | |
| Hypoxia inducible factor 1 alpha subunit inhibitor antibody | |
| Hypoxia inducible factor asparagine hydroxylase antibody | |
| Hypoxia-inducible factor 1-alpha inhibitor antibody | |
| Hypoxia-inducible factor asparagine hydroxylase antibody | |
| Peptide aspartate beta dioxygenase antibody |
靶标信息
Hydroxylates HIF-1 alpha at ‘Asn-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
产品来源
洱畔科技实验室
