Anti-GSK3α/β Rabbit Polyclonal antibody
Specifications
| Product Cat#: | AB-06-5079 | |
| Product type: | Primary antibody | |
| Antigen: | GSK3α/β | |
| Immunogen: | Synthesized peptide derived from the Internal region of human Reg IV. | |
| Species immunized: | Rabbit | |
| Isotype: | IgG | |
| Applications: | Western Blot (1:500-1:2000); Immunohistochemistry-Paraffin (1:100-300) | |
| Reactivity: | Human, Mouse, Rat | |
| Clonality (clone number): | Polyclonal | |
| Form: | Liquid | |
| Buffer: | 1*PBS buffer (pH 7.4), 0.5% BSA, 50% Glycerol, 0.02% NaN3. | |
| Concentration: | 1 mg/mL | |
| Purity: | Immunogen affinity purified. | |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. | |
| Alternative names: | GSK3A antibody | |
| Glycogen synthase kinase-3 alpha antibody | ||
| GSK-3 alpha antibody | ||
| Serine/threonine-protein kinase GSK3A antibody | ||
| GSK3B antibody | ||
| Glycogen synthase kinase-3 beta antibody | ||
| GSK-3 beta antibody | ||
| Serine/threonine-protein kinase GSK3B antibody | ||
| GSK3α/β |
靶标信息
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1 (PubMed:11749387, PubMed:17478001, PubMed:19366350).
Requires primed phosphorylation of the majority of its substrates (PubMed:11749387, PubMed:17478001, PubMed:19366350).
Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:11749387, PubMed:17478001, PubMed:19366350).
Regulates glycogen metabolism in liver, but not in muscle (By similarity).
May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:10868943, PubMed:17478001).
In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin (PubMed:17229088).
Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease (PubMed:12761548).
May be involved in the regulation of replication in pancreatic beta-cells (By similarity).
Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity).
Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity).
Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions which activates KAT5/TIP60 acetyltransferase activity and promotes acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:30704899).
Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity).
Phosphorylates mTORC2 complex component RICTOR at ‘Thr-1695’ which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075).
产品来源
洱畔科技实验室
