Anti-GCLM antibody
产品特性
| Product Cat#: | AB-06-1869 |
| Product type: | Primary antibody |
| Antigen: | GCLM |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:1000); Immunohistochemistry (1:50-1:100); Flow Cytometry (1:50-1:100); Immunocytochemistry (1:50-1:200); Immunofluorescence; Immunoprecipitation |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal, JM93-61 |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Gamma ECS regulatory subunit antibody |
| Gamma-ECS regulatory subunit antibody | |
| Gamma-glutamylcysteine synthetase regulatory subunit antibody | |
| GCLM antibody | |
| GCS light chain antibody | |
| GLCLR antibody | |
| Glutamate cysteine ligase regulatory subunit antibody | |
| Glutamatecysteine ligase modifier subunit antibody | |
| Glutamatecysteine ligase regulatory subunit antibody | |
| GSC light chain antibody | |
| GSH0_HUMAN antibody |
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靶标信息
Gamma-glutamylcysteine synthetase (γ-GCS) is the rate limiting enzyme for glutathione (L-gamma-glutamyl-L-cysteinylglycine, GSH) synthesis. GSH is ubiquitous in mammalian cells as a vital intra- and extracellular protective antioxidant. γ-GCS is a heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. The human gamma-GCS gene encoding the 367 amino acid catalytic subunit maps to chromosome 6p12. The human γ-GCS gene encoding the regulatory subunit maps to chromosome 1p22-p21. The two subunits of γ-GCS form a heterodimeric zinc metalloprotein that gains activity through formation of a reversible disulfide bond.
产品来源
洱畔科技实验室
