Anti-GBA antibody (KO Validated)
产品特性
| Product Cat#: | AB-06-1863 |
| Product type: | Primary antibody |
| Antigen: | GBA |
| Immunogen: | Synthetic peptide within Human GBA aa 477-534/536. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:1000-1:5000); Immunohistochemistry-Paraffin (1:50-1:200) |
| Reactivity: | Human, Rat, Mouse |
| Clonality (clone number): | Monoclonal (JM10-76) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | Acid beta glucosidase antibody |
| Acid beta-glucosidase antibody | |
| Alglucerase antibody | |
| Beta glucocerebrosidase antibody | |
| BETA GLUCOSIDASE, ACID antibody | |
| Beta-glucocerebrosidase antibody | |
| betaGC antibody | |
| D glucosyl N acylsphingosine glucohydrolase antibody | |
| D-glucosyl-N-acylsphingosine glucohydrolase antibody | |
| EC 3.2.1.45 antibody | |
| GBA antibody | |
| Gba protein antibody | |
| GBA1 antibody | |
| GC antibody | |
| GCase antibody | |
| GCB antibody | |
| GLCM_HUMAN antibody | |
| GLUC antibody | |
| Glucocerebrosidase (alt.) antibody | |
| Glucocerebrosidase antibody | |
| GLUCOCEREBROSIDASE PSEUDOGENE antibody | |
| Glucosidase beta antibody | |
| Glucosidase, beta, acid antibody | |
| Glucosidase, beta; acid (includes glucosylceramidase) antibody | |
| Glucosylceramidase antibody | |
| Imiglucerase antibody | |
| Lysosomal glucocerebrosidase antibody | |
| OTTHUMP00000033992 antibody | |
| OTTHUMP00000033993 antibody |
靶标信息
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:9201993, PubMed:24211208). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation (PubMed:19279011). Also plays a role in cholesterol metabolism (PubMed:24211208, PubMed:26724485). May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol (PubMed:24211208, PubMed:26724485). The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction (PubMed:24211208). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (PubMed:26724485). Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol (PubMed:24211208, PubMed:26724485).
产品来源
洱畔科技实验室
