Anti-GABR B3 antibody
Specifications
| Product Cat#: | AB-06-1818 |
| Product type: | Primary antibody |
| Antigen: | GABR B3 |
| Immunogen: | KLH conjugated synthetic peptide derived from human GABR B3/GABA A Receptor beta 3 31-130/473 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:500-1:2000); Flow Cytometry (1μg/Test) |
| Reactivity: | Human, Mouse, Rat, Chicken, Pig, Cow, Horse |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Alternative names: | GABA A Receptor beta 3 |
| ECA5 | |
| GABA alpha receptor beta-2 subunit | |
| GABA(A) receptor subunit beta-3 | |
| GABAA receptor beta 3 subunit | |
| GABAA receptor subunit beta 3 | |
| GABR B3 | |
| Gabrb3 | |
| Gamma aminobutyric acid (GABA) A receptor beta 3 | |
| Gamma aminobutyric acid receptor subunit beta 3 | |
| Gamma-aminobutyric acid receptor subunit beta-3 | |
| GBRB3_HUMAN |
靶标信息
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:18514161, PubMed:22303015, PubMed:26950270, PubMed:22243422, PubMed:24909990). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity (PubMed:25489750). The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286). Plays an important role in somatosensation and in the production of antinociception (By similarity).
产品来源
洱畔科技实验室
