Anti-Fragilis antibody
产品特性
| Product type: | Primary antibody |
| Antigen: | Fragilis |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:900-1:5000); Immunohistochemistry (1:40-1:100); Flow Cytometry (1:40-1:100); Immunocytochemistry (1:40-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JU73-02) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer (pH7.4), 1% BSA, 40% glycerol, 0.05% NaN3. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | 1 8U antibody |
| Fragilis antibody | |
| IFITM3 antibody | |
| IFM3_HUMAN antibody | |
| Interferon induced transmembrane protein 3 (1 8U) antibody | |
| Interferon Induced Transmembrane Protein 3 antibody | |
| Interferon inducible antibody | |
| Interferon inducible protein 1 8U antibody | |
| Interferon Inducible Protein 15 antibody | |
| Interferon Inducible Protein Homolog antibody | |
| Interferon-induced transmembrane protein 3 antibody | |
| Interferon-inducible protein 1-8U antibody | |
| IP15 antibody |
靶标信息
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
产品来源
洱畔科技实验室
