Anti-FBXO39 antibody
产品特性
| Product Cat#: | AB-06-1683 |
| Product type: | Primary antibody |
| Antigen: | FBXO39 |
| Immunogen: | KLH conjugated synthetic peptide derived from mouse XAF1 151-250/273 |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:2000); Immunohistochemistry-Paraffin (1:500-1:800) |
| Reactivity: | Mouse, Rat |
| Clonality (clone number): | Polyclonal |
| Form: | Liquid |
| Buffer: | 0.01 M TBS(pH7.4) with 1% BSA; 0.03% Proclin 300 and 50% Glycerol. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | XIAP-associated factor 1 |
| BIRC4 binding protein | |
| BIRC4-binding protein | |
| XAF1 | |
| XAF1_MOUSE | |
| XIAPAF1 | |
| BIRC4 binding protein | |
| BIRC4 binding protein | |
| BIRC4BP | |
| HSXIAPAF1 | |
| HSXIAPAF1 | |
| XAF 1 | |
| XIAP associated factor 1 | |
| Fbxo39 |
靶标信息
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity).
产品来源
洱畔科技实验室
