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Anti-FBXL17 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-1677
Anti-FBXL17 antibody
洱畔/Erpan Tech 有货

产品特性        

Product Cat#: AB-06-1677
Product type: Primary antibody
Antigen: FBXL17
Immunogen: KLH conjugated synthetic peptide derived from human FBXL17 451-550/701
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:400-1:2000)
Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: 0.01 M TBS(pH7.4) with 1% BSA; 0.03% Proclin 300 and 50% Glycerol.
Concentration: 1 mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: F box and leucine rich repeat protein 17
F box only protein 13
F box/LRR repeat protein 17
F-box and leucine-rich repeat protein 17
F-box only protein 13
F-box/LRR-repeat protein 17
FBL17
FBX13
Fbxl17
FBXO13
FBXL13
FXL17_HUMAN
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靶标信息

Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) . FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 . The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction . The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity).

产品来源

洱畔科技实验室

文件下载

Material-Safety-Data-Sheet.pdf (下载61107 )