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Anti-EphB2 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-1571
Anti-EphB2 antibody
洱畔/Erpan Tech 有货

产品特性        

Product type: Primary antibody
Antigen: EphB2
Immunogen: KLH conjugated synthetic peptide derived from human EphB2 R 101-200/1055
Species immunized: Mouse/Rabbit
Isotype: IgG
Applications: Western Blot (1:200-1:1000);Immunohistochemistry-Paraffin (1:250-800)
Reactivity: Human, Mouse, Rat, Chicken, Dog
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration: 1mg/ml
Purity: Protein A  purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Eph receptor B2
Developmentally regulated EPH related tyrosine kinase
DRT
ELK related protein tyrosine kinase
EPH tyrosine kinase 3
EphB2
Ephrin type B receptor 2
EPHT 3
ERK
ETECK
Nuk
Prkm 5
Receptor protein tyrosine kinase HEK 5, Sek 3
Tyro 5
Tyrosine protein kinase receptor CEK 5
Tyrosine protein kinase receptor EPH 3
Tyrosine protein kinase receptor QEK 5
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靶标信息

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

产品来源

洱泮科技实验室

文件下载

Material-Safety-Data-Sheet.pdf (下载14217 )