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Anti-EphA7 antibody

产品货号 产品 品牌 单位 存货 价格 促销价 数量  
AB-06-1570
Anti-EphA7 antibody
洱畔/Erpan Tech 有货

产品特性        

Product type: Primary antibody
Antigen: EphA7
Immunogen: KLH conjugated synthetic peptide derived from human EphA7 181-280/998
Species immunized: Rabbit
Isotype: IgG
Applications: Western Blot (1:200-1:1500); Immunohistochemistry-Paraffin (1:250-800)
Reactivity: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit
Clonality (clone number): Polyclonal
Form: Liquid
Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration: 1mg/ml
Purity: Protein A affinity purified
Storage: Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles.
Alternative names: Cek 11
Developmental kinase 1
EBK
EHK-3
EHK3
EK11
Embryonic brain kinase
Eph homology kinase 3
Eph receptor A7
EPH-like kinase 11
EphA7
EPHA7_HUMAN
Ephrin receptor Eph A7
Ephrin type A receptor 7
Ephrin type-A receptor 7
hEK11
MDK 1
Receptor protein tyrosine kinase HEK 11
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靶标信息

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

产品来源

洱泮科技实验室

文件下载

Material-Safety-Data-Sheet.pdf (下载14217 )