Anti-E-Cadherin antibody
产品特性
| Product Cat#: | AB-06-1475 |
| Product type: | Primary antibody |
| Antigen: | E Cadherin |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot ( 1:1000-1:5000 ); Immunohistochemistry ( 1:80-1:200 ); Immunocytochemistry ( 1:80-1:200 ); Immunoprecipitation; Immunofluorescence; Flow Cytometry ( 1:40-1:100 ) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal ( SY0287 ) |
| Form: | Liquid |
| Buffer: | Tris-HCl buffer ( pH7.4 ), 1 % BSA, 40 % glycerol, 0.05 % NaN3. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | Arc 1 Antibody |
| CADH1_HUMAN Antibody | |
| Cadherin 1 Antibody | |
| Cadherin 1 Type 1 E-cadherinAntibody | |
| Cadherin1 Antibody | |
| CAM 120/80 Antibody | |
| CD 324 Antibody | |
| CD324 Antibody | |
| CD324 Antigen Antibody | |
| Cdh1 Antibody | |
| CDHE Antibody | |
| E-Cad/CTF3 Antibody | |
| E-cadherin Antibody | |
| ECAD Antibody | |
| Epithelial cadherin Antibody | |
| Epithelial Calcium Dependant Adhesion Protein Antibody | |
| LCAM Antibody | |
| Liver Cell Adhesion Molecule Antibody | |
| UVO Antibody | |
| Uvomorulin Antibody |
靶标信息
Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.(Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria.
产品来源
洱畔科技实验室
验证图片
Fig1: Western blot analysis of E-Cadherin on different lysates with Rabbit anti-E-Cadherin antibody (AB-06-1475) at 1/5,000 dilution. Lane 1: MCF7 cell lysate; Lane 2: MDA-MB-231 cell lysate (negative); Lane 3: HT-29 cell lysate; Lane 4: HCT 116 cell lysate; Lane 5: A431 cell lysate; Lane 6: Caco-2 cell lysate. Lysates/proteins at 20 µg/Lane. Predicted band size: 97 kDa; Observed band size: 80~120 kDa