Anti-DEK antibody
产品特性
| Product Cat#: | AB-06-1350 |
| Product type: | Primary antibody |
| Antigen: | DEK |
| Immunogen: | Recombinant protein corresponding to C-terminal human DEK. |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:400-1:1000); Immunoprecipitation (1:50-1:200) |
| Reactivity: | Human |
| Clonality (clone number): | Monoclonal (JB36-32) |
| Form: | Liquid |
| Buffer: | 1*TBS (pH 7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1 mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | D6S231E antibody |
| Dek antibody | |
| DEK gene antibody | |
| DEK oncogene antibody | |
| DEK oncogene DNA binding antibody | |
| DEK_HUMAN antibody | |
| Protein DEK antibody |
靶标信息
The mammalian nuclear phosphoprotein DEK is implicated in multiple cellular processes, including transcriptional regulation, mRNA processing, and chromatin remodeling, and is associated with a number of clinical autoimmune and neoplastic conditions. DEK, an abundant chromatin-associated protein, changes the topology of DNA in chromatin in vitro. Although first identified in a fusion with the CAN/Nup214 nucleoporin protein in a specific subtype of acute myelogenous leukemia, DEK is also an autoantigen in patients with Pauciarticular onset juvenile rheumatoid arthritis. Furthermore, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia. The human DEK gene maps to chromosome 6p22.3.
产品来源
洱畔科技实验室
