Anti-Dnmt1 antibody
产品特性
| Product type: | Primary antibody |
| Antigen: | DARPP32 |
| Immunogen: | Recombinant protein |
| Species immunized: | Rabbit |
| Isotype: | IgG |
| Applications: | Western Blot (1:2000-1:5000); Immunohistochemistry (1:100-1:200); Flow Cytometry (1:50-1:200); Immunocytochemistry (1:100-1:200) |
| Reactivity: | Human, Mouse, Rat |
| Clonality (clone number): | Monoclonal |
| Form: | Liquid |
| Buffer: | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Concentration: | 1mg/ml |
| Purity: | Protein A affinity purified |
| Storage: | Aliquot and freeze at -20℃. Avoid multiple freeze/thaw cycles. |
| Alternative names: | DARPP 32 antibody |
| DARPP-32 antibody | |
| Dopamine and cAMP regulated neuronal phosphoprotein 32 antibody | |
| Dopamine and cAMP regulated neuronal phosphoprotein antibody | |
| Dopamine and cAMP regulated phosphoprotein antibody | |
| Dopamine and cAMP regulated phosphoprotein DARPP 32 antibody | |
| Dopamine and cAMP regulated phosphoprotein DARPP32 antibody | |
| Dopamine- and cAMP-regulated neuronal phosphoprotein antibody | |
| FLJ20940 antibody | |
| IPPD antibody | |
| Neuronal phosphoprotein DARPP 32 antibody | |
| PPP1R1B antibody | |
| PPR1B_HUMAN antibody | |
| Protein phosphatase 1 regulatory (inhibitor) subunit 1B antibody | |
| Protein phosphatase 1 regulatory inhibitor subunit 1B antibody | |
| Protein phosphatase 1 regulatory subunit 1B antibody |
靶标信息
Dopaminergic signaling pathways, which are essential for multiple brain functions, are abnormal in several neurological disorders, such as schizophrenia, Parkinson’s disease and drug abuse. DARPP-32 (for dopamine and adenosine 3′,5′-monophosphate-regulated phosphoprotein) is abundant in neurons that receive dopaminergic input. Activation of PKA and the consequent phosphorylation of DARPP-32 on threonine occurs in response to dopamine acting upon D1-like receptors. Dopamine interaction with D2-like receptors results in the inhibition of PKA activation, the activation of protein phosphatase 2B and the consequent dephosphorylation of DARPP-32. Neurotransmitters other than dopamine may also be able to stimulate the phosphorylation or dephosphorylation of DARPP-32. Phosphorylated DARPP-32 is a potent inhibitor of PP-1.
产品来源
洱畔科技实验室
